Last update: July 11, 2017

Benznidazole

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Antiprotozoan drug used for the treatment of American Trypanosomiasis (Trypanosoma cruzi) or Chagas Disease (see specific info).

It is excreted into breast milk in small amounts and there have not been observed problems in infants from treated mothers (Garcia-Bournissen 2015, Vela-Bahena 2015).

Benznidazole has been very well tolerated when administered directly to infants and newborns (Altcheh 2011, Chippaux 2013).


See below the information of this related product:

Alternatives

We do not have alternatives for Benznidazole since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Benznidazole in other languages or writings:

Group

Benznidazole belongs to this group or family:

Tradenames

Main tradenames from several countries containing Benznidazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 92 %
Molecular weight 260 daltons
Protein Binding 44 %
Tmax 3 - 4 hours
T1/2 10 - 14 hours
Theoretical Dose 0,6 (0,05 - 1,5) mg/Kg/d
Relative Dose 6 (0,5 - 15) %
Relat.Ped.Dose 6 (0,5 - 15) %

References

  1. García-Bournissen F, Moroni S, Marson ME, Moscatelli G, Mastrantonio G, Bisio M, Cornou L, Ballering G, Altcheh J. Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease. Arch Dis Child. 2015 Abstract Full text (link to original source) Full text (in our servers)
  2. Vela-Bahena LE, Vergara R, Vite L, Ramos C. Tratamiento posparto en una paciente con enfermedad de Chagas, sin interrupción de la lactancia. [Postpartum treatment without interrupting breastfeeding in a patient with Chagas disease]. Ginecol Obstet Mex. 2015 Abstract Full text (link to original source) Full text (in our servers)
  3. García-Bournissen F, Moroni S, Marson ME, Moscatelli G, Mastrantonio G, Bisio M, Cornou L, Ballering G, Altcheh J. Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease. Arch Dis Child. 2014 Abstract
  4. Marson ME, Padró JM, Reta MR, Altcheh J, García-Bournissen F, Mastrantonio G. A simple and efficient HPLC method for benznidazole dosage in human breast milk. Ther Drug Monit. 2013 Abstract
  5. Chippaux JP, Salas-Clavijo AN, Postigo JR, Schneider D, Santalla JA, Brutus L. Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia. Trans R Soc Trop Med Hyg. 2013 Abstract Full text (in our servers)
  6. Altcheh J, Moscatelli G, Moroni S, Garcia-Bournissen F, Freilij H. Adverse events after the use of benznidazole in infants and children with Chagas disease. Pediatrics. 2011 Abstract
  7. Pérez JL, Carranza C, Mateos F. Antiparasitarios. Revisión de los fármacos útiles en el tratamiento de parasitosis clásicas y emergentes. \ [Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases]. Rev Esp Quimioter. 2009 Jun;22(2):93-105. Review. Spanish. Abstract Full text (link to original source) Full text (in our servers)
  8. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  9. Shikanai-Yasuda MA, Lopes MH, Tolezano JE, Umezawa E, Amato Neto V, Barreto AC, Higaki Y, Moreira AA, Funayama G, Barone AA, et al. [Acute Chagas' disease: transmission routes, clinical aspects and response to specific therapy in diagnosed cases in an urban center]. Rev Inst Med Trop Sao Paulo. 1990 Abstract Full text (in our servers)
  10. Raaflaub J, Ziegler WH. Single-dose pharmacokinetics of the trypanosomicide benznidazole in man. Arzneimittelforschung. 1979 Abstract

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