Last update: Feb. 28, 2018

(+)-2-(6-Methoxy-2-naphthyl)propionic acid

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Oral dosage twice daily.

Low excreted into breast milk (Reece-Stremtan2017, Østensen 2007, Jamali 1982). However, somnolence in 10% of breastfed infants has been reported (Ito 1993).

A case of acute anemia due to hemorrhage by coagulation disturbance in an one week aged infant (Fidalgo 1989).

Long-term use while breastfeeding (Davanzo 2014, Sachs 2013) or in case of newborn jaundice is not recommended because a competitive effect on liver metabolism has been shown (Risser 2009, Janssen 2000).
Short-term (1 week) or sporadic use has a low risk (Jamali 1982).

American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

(+)-2-(6-Methoxy-2-naphthyl)propionic acid is Naproxen in Chemical name.

Is written in other languages:

(+)-2-(6-Methoxy-2-naphthyl)propionic acid is also known as

Group

(+)-2-(6-Methoxy-2-naphthyl)propionic acid belongs to this group or family:

Tradenames

Main tradenames from several countries containing (+)-2-(6-Methoxy-2-naphthyl)propionic acid in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 95 %
Molecular weight 230 daltons
Protein Binding 99,7 %
VD 0,1 l/Kg
Tmax 1 - 4 hours
T1/2 12 - 15 hours
M/P ratio 0,01 -
Theoretical Dose 0,4 mg/Kg/d
Relative Dose 4,8 %
Relat.Ped.Dose 2,0 - 2,6 %

References

  1. Reece-Stremtan Sarah, Campos Matilde, Kokajko Lauren, and The Academy of Breastfeeding Medicine. Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2017. Breastfeed Med. 2017 Nov;12(9):500-506. Full text (link to original source) Full text (in our servers)
  2. Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014 Abstract
  3. Worthington I, Pringsheim T, Gawel MJ, Gladstone J, Cooper P, Dilli E, Aube M, Leroux E, Becker WJ; Canadian Headache Society Acute Migraine Treatment Guideline Development Group. Canadian Headache Society Guideline: acute drug therapy for migraine headache. Can J Neurol Sci. 2013 Abstract Full text (in our servers)
  4. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  5. Risser A, Donovan D, Heintzman J, Page T. NSAID prescribing precautions. Am Fam Physician. 2009 Abstract Full text (link to original source) Full text (in our servers)
  6. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  7. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med. 2000 Abstract Full text (link to original source) Full text (in our servers)
  8. Davies NM, Anderson KE. Clinical pharmacokinetics of naproxen. Clin Pharmacokinet. 1997 Abstract
  9. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  10. Fidalgo I, Correa R, Gómez Carrasco JA, Martínez Quiroga F. Anemia aguda, rectorragia y hematuria asociadas a la ingestión de naproxen. [Acute anemia, rectorrhagia and hematuria caused by ingestion of naproxen]. An Esp Pediatr. 1989 Abstract
  11. Fidalgo I, Correa R, Gómez Carrasco JA, Martínez Quiroga F. [Acute anemia, rectorrhagia and hematuria caused by ingestion of naproxen]. An Esp Pediatr. 1989 Abstract
  12. Jamali F, Stevens DR. Naproxen excretion in milk and its uptake by the infant. Drug Intell Clin Pharm. 1983 Abstract
  13. Brogden RN, Pinder RM, Sawyer PR, Speight TM, Avery GS. Naproxen: a review of its pharmacological properties and therapeutic efficacy and use. Drugs. 1975 Abstract

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