Last update Jan. 17, 2016

Voriconazole

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Antifungal drug with similar structure than fluconazole available for systemic, oral and intravenous use, and topically for ophthalmic purposes.

A latest update no published data on excretion in breast milk were found.

Pharmacokinetic data indicates that it may likely pass into the milk in amounts that could be significant.
Authorized use in children as young as 2 years of age. It has been used in 10-months-old infants.

Until more published data on this drug regarding breastfeeding is available, safer alternatives of better known drugs, should be preferable, especially during the neonatal period and in case of prematurity.

The small dose and poor absorption into plasma of most ophthalmic preparations makes it unlikely the pass of the drug into breast milk in significant amount.

Alternatives

  • Fluconazole ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Voriconazole in other languages or writings:

Groups

Voriconazole belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Voriconazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 96 %
Molecular weight 349 daltons
Protein Binding 58 %
VD 2 - 4.6 l/Kg
Tmax 1 - 2 hours
6 hours

References

  1. Neely M, Rushing T, Kovacs A, Jelliffe R, Hoffman J. Voriconazole pharmacokinetics and pharmacodynamics in children. Clin Infect Dis. 2010 Abstract
  2. Walsh TJ, Driscoll T, Milligan PA, Wood ND, Schlamm H, Groll AH, Jafri H, Arrieta AC, Klein NJ, Lutsar I. Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children. Antimicrob Agents Chemother. 2010 Abstract
  3. Theuretzbacher U, Ihle F, Derendorf H. Pharmacokinetic/pharmacodynamic profile of voriconazole. Clin Pharmacokinet. 2006 Abstract

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