Last update Dec. 29, 2024

Nystatin

Compatible

Safe product and/or breastfeeding is the best option.

Nystatin is a polyene ionophore antifungal used for the prevention and treatment of cutaneous, mucocutaneous and gastrointestinal fungal infections, particularly those caused by Candida species. Oral or topical, cutaneous, oral or vaginal administration.

At the date of last update, we found no published data on its excretion in breast milk.

The absorption of nystatin in the gastrointestinal tract is minimal and is nil through the skin or mucous membranes when applied topically. No detectable plasma concentrations are reached after oral, topical or vaginal administration, so it cannot reach breast milk. (Butler 2014, Ilett 2005, Mactal 2001)

Medication approved for use in young infants and neonates. (Kiat 2013, Hoeger 2010, de Vries 2004, Brent 2001)

Creams, gels and other locally applied products containing kerosene (mineral oil) should not be applied to the nipple so that they are not absorbed by the infant. (Concin 2008, Noti 2003)

Several medical societies and expert authors consider the use of this medication safe during breastfeeding. (Briggs 2015, Schaefer 2015, Amir 2013, Ilett 2005)

WHO list of essential medicines: compatible with breastfeeding. (WHO-UNICEF 2002)

Alternatives

We do not have alternatives for Nystatin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Nystatin is also known as


Nystatin in other languages or writings:

Tradenames

Main tradenames from several countries containing Nystatin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 926 daltons
pKa 3.61 -

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. Kiat-Amnuay S, Bouquot J. Breastfeeding keratosis: this frictional keratosis of newborns may mimic thrush. Pediatrics. 2013 Abstract Full text (link to original source)
  3. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract
  4. Hoeger PH, Stark S, Jost G. Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study. J Eur Acad Dermatol Venereol. 2010 Abstract
  5. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  6. Nystatin. Drug Summary. 2006 Full text (in our servers)
  7. Ilett KF, Kristensen JH. Drug use and breastfeeding. Expert Opin Drug Saf. 2005 Abstract
  8. Nistatina. Ficha técnica. 2004 Full text (in our servers)
  9. de Vries TW, Wewerinke ME, de Langen JJ. [Near asphyxiation of a neonate due to miconazole oral gel]. Ned Tijdschr Geneeskd. 2004 Abstract
  10. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  11. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  12. Brent NB. Thrush in the breastfeeding dyad: results of a survey on diagnosis and treatment. Clin Pediatr (Phila). 2001 Abstract
  13. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract

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