Last update June 23, 2022

Thioridazine

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Typical, first generation antipsychotic. Prochlorperazine is a phenothiazine derivative with general properties similar to those of chlorpromazine. It has been used in the treatment of schizophrenia and in generalized anxiety disorder. Oral administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very wide volume of distribution and high percentage of protein binding) make it highly unlikely that significant quantities will pass into breast milk.

Withdrawn from the market in many countries from 2000-2005 due to increased risk of ventricular arrhythmias. (Handley 2016, Timell 2000)


See below the information of this related product:

Alternatives

  • Chlorpromazine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Olanzapine (Safe substance and/or breastfeeding is the best option.)
  • Perphenazine (Safe substance and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe substance and/or breastfeeding is the best option.)
  • Trifluoperazine Hydrochloride (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Thioridazine in other languages or writings:

Groups

Thioridazine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Thioridazine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 371 daltons
Protein Binding 95 %
VD 1.8- 6.7 l/Kg
pKa 9.5 -
Tmax 4 hours
T½ 21 - 25 hours

References

  1. Handley S, Patel MX, Flanagan RJ. Antipsychotic-related fatal poisoning, England and Wales, 1993-2013: impact of the withdrawal of thioridazine. Clin Toxicol (Phila). 2016 Jul;54(6):471-80. Abstract
  2. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract
  3. Timell AM. Thioridazine: re-evaluating the risk/benefit equation. Ann Clin Psychiatry. 2000 Sep;12(3):147-51. Abstract

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