Last update June 23, 2022

Thioperazine

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Typical, first-generation antipsychotic. It is a phenothiazine with properties similar to those of chlorpromazine. It is used in the treatment of schizophrenia, mania, and other psychoses. Single-dose oral administration.

At the date of the last update, there was no published data available on its excretion in human milk.

Product with very few and old bibliographic references, without known pharmacokinetic data and marketed in few countries.

It can cause galactorrhea. (Mendels 1964)

Known safer alternatives are preferable (Parikh 2014), especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

Alternatives

  • Chlorpromazine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Olanzapine (Safe product and/or breastfeeding is the best option.)
  • Perphenazine (Safe product and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe product and/or breastfeeding is the best option.)
  • Trifluoperazine Hydrochloride (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Thioperazine is also known as Thioproperazine Mesilate.


Thioperazine in other languages or writings:

Groups

Thioperazine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Thioperazine in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 639 daltons

References

  1. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract
  2. MENDELS J. THIOPROPERAZINE-INDUCED LACTATION. Am J Psychiatry. 1964 Aug;121:190-1. No abstract available. Abstract

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