Last update Aug. 6, 2017


Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Used alone or in combination with sofosbuvir in the treatment of hepatitis C.

Since the last update we have not found published data on its excretion in breast milk.

Its pharmacokinetic data (slightly elevated molecular weight and very high percentage of plasma protein binding) make it very unlikely that significant amounts will pass into milk, so that although there is disagreement (Thompson 2016), other experts believe that treatment with Simeprevir, on its own or in combination with Sofosbuvir is not contraindicated during breastfeeding (LactMed 2016,

See below the information of these related products:

  • Maternal Hepatitis C Infection ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Sofosbuvir (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

سيميبريفير is Simeprevir in Arabic.

Is written in other languages:

سيميبريفير is also known as


سيميبريفير belongs to this group or family:


Main tradenames from several countries containing سيميبريفير in its composition:


Variable Value Unit
Oral Bioavail. 62 %
Molecular weight 750 daltons
Protein Binding 99.9 %
Tmax 4 - 6 hours
10 - 41 hours


  1. LactMed. Simeprevir. Full Record Display. 2017 Full text (in our servers)
  2. EMA. Simeprevir. Drug Summary. 2017 Full text (in our servers)
  3. EMA. Simeprevir. Ficha técnica. 2017 Full text (in our servers)
  4. Thompson AJ. Australian recommendations for the management of hepatitis C virus infection: a consensus statement. Med J Aust. 2016 Abstract Full text (link to original source) Full text (in our servers)
  5. Spera AM, Eldin TK, Tosone G, Orlando R. Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women? World J Hepatol. 2016 Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM