Last update Sept. 4, 2022


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Typical, first-generation antipsychotic. Prochlorperazine is a phenothiazine derivative with general properties similar to those of chlorpromazine. It is used in the prevention and treatment of nausea and vomiting, vertigo, schizophrenia, bipolar disorder, and severe anxiety. Oral, rectal or parenteral administration two to three times a day.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very wide volume of distribution (Taylor 1987) and high percentage of protein binding) make it highly unlikely that significant quantities will pass into breast milk.

Its very low oral bioavailability (Isah 1992, Taylor 1987) makes it difficult for it to pass to the infant plasma from ingested breast milk, except in premature infants and in the immediate neonatal period in which there may be greater intestinal permeability.

Some cases of galactorrhea have been described. (Hooper 1961)

Various medical societies and expert authors consider the punctual use of this medication to be safe during breastfeeding. (LactMed, Worthington 2013)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Hale, Reece 2017, Parikh 2014, Mahadevan 2006, Lee 1993), especially during the neonatal period and in the event of prematurity.

See below the information of this related product:


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Prochlorperazine is also known as

Prochlorperazine in other languages or writings:


Main tradenames from several countries containing Prochlorperazine in its composition:


Variable Value Unit
Oral Bioavail. 12.5 %
Molecular weight 374 daltons
Protein Binding 91 - 99 %
VD 20 - 22 l/Kg
Tmax 5 hours
8 - 9 hours
M/P ratio 0.01 -


  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from Consulted on April 10, 2024 Full text (link to original source)
  3. Reece-Stremtan Sarah, Campos Matilde, Kokajko Lauren, and The Academy of Breastfeeding Medicine. Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2017. Breastfeed Med. 2017 Nov;12(9):500-506. Full text (link to original source) Full text (in our servers)
  4. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract
  5. Worthington I, Pringsheim T, Gawel MJ, Gladstone J, Cooper P, Dilli E, Aube M, Leroux E, Becker WJ; Canadian Headache Society Acute Migraine Treatment Guideline Development Group. Canadian Headache Society Guideline: acute drug therapy for migraine headache. Can J Neurol Sci. 2013 Sep;40(5 Suppl 3):S1-S80. Review. Abstract Full text (in our servers)
  6. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  7. Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia. 1993 Jul;48(7):616-25. Review. Abstract Full text (link to original source) Full text (in our servers)
  8. Isah AO, Rawlins MD, Bateman DN. The pharmacokinetics and effects of prochlorperazine in elderly female volunteers. Age Ageing. 1992 Jan;21(1):27-31. Abstract
  9. Taylor WB, Bateman DN. Preliminary studies of the pharmacokinetics and pharmacodynamics of prochlorperazine in healthy volunteers. Br J Clin Pharmacol. 1987 Feb;23(2):137-42. Abstract Full text (link to original source)
  10. HOOPER JH Jr, WELCH VC, SHACKELFORD RT. Abnormal lactation associated with tranquilizing drug therapy. JAMA. 1961 Abstract

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