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Central psychostimulant drug that is used as an anorectic in the treatment of obesity. It has similar actions than Dexamphetamine. Oral administration in a daily dose.
At latest update no published data were found on excretion into breast milk.
Pharmacokinetic data (low molecular weight and low protein binding) make it likely the passage into milk in an amount that may be significant.
Its T1/2 of 20 hours would make it necessary to stop breastfeeding for about 140 hours after its administration.
It could cause insomnia, irritability and anorexia in the infant.
Given the increased risk for cardiac valvular disorders and psychotic reactions, the European Medicines Agency (EMA) ordered the withdrawal from marketing in the European Union on 2000. (AEMPS 2000)
There is good quality evidence that exclusive breastfeeding helps to regain pre-pregnancy weight earlier than if breastfeeding is partial (mixed) or there is no breastfeeding, and that prolonged breastfeeding helps maintain that loss and as well as body fat loss.(Jayasinghe 2021, Schalla 2017, López 2016, Jarlenski 2014, Sámano 2013, Neville 2014, Hatsu 2008, Dewey 2004, 2001 y 1993, Kramer 1993)