Last update Dec. 2, 2014


Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Anti-obesity product with a peripheral acting mechanism. Absorption of ingested fat is reduced by 35% due to local neutralization of lipase activity in the gut. Orlistat is not absorbed.

At latest update, relevant information on excretion into breast milk was not found. However, because of pharmacokinetic data (a moderately high molecular-weight, a nil absorption, a high protein-binding-capacity), excretion of Orlistat into breast milk in significant levels is unlikely. Due to a lack of absorption, serum levels are likely nil.

On long-standing basis, it may affect absorption of liposoluble vitamins (A, D, E, K) and beta-carotenes. This would be a reason to recommend a varied diet which should be rich in consumption of fruits, vegetables. Vitamin supplementation should also be considered.

Nutritional status of the nursing mother should be monitored.

Most of breastfeeding mothers recover the weight previous of pregnancy sooner than those who are not.


  • Hypocaloric Diet ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Orlistat belongs to this group or family:


Main tradenames from several countries containing Orlistat in its composition:


Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 496 daltons
Protein Binding 99 %
Tmax 8 hours
1 - 2 hours


  1. AEMPS. Orlistat. Ficha técnica. 2014 Full text (in our servers)
  2. Mittendorfer B, Ostlund RE Jr, Patterson BW, Klein S. Orlistat inhibits dietary cholesterol absorption. Obes Res. 2001 Abstract
  3. Guerciolini R. Mode of action of orlistat. Int J Obes Relat Metab Disord. 1997 Abstract
  4. Melia AT, Koss-Twardy SG, Zhi J. The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers. J Clin Pharmacol. 1996 Abstract
  5. Zhi J, Melia AT, Eggers H, Joly R, Patel IH. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol. 1995 Abstract

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