Last update June 26, 2022

Phenelzine Sulfate

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Antidepressant used in the treatment of atypical depression. Oral administration 3 to 4 times a day.

Since the last update we have not found any published data on its excretion in breast milk.

The few known pharmacokinetic data do not allow to predict the possible passage into breast milk.

It can cause galactorrhea and increased prolatin levels. (Meltzer 1982, Segal 1969).

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.

See below the information of this related product:

  • Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Phenelzine Sulfate in other languages or writings:


Phenelzine Sulfate belongs to these groups or families:


Main tradenames from several countries containing Phenelzine Sulfate in its composition:


Variable Value Unit
Oral Bioavail. Alta - Hig %
Molecular weight 136 daltons
Tmax 0.75 hours
11.6 hours


  1. Pfizer. Phenelzine (Nardil). Drug Summary. 2009 Full text (in our servers)
  2. Baker GB, Urichuk LJ, McKenna KF, Kennedy SH. Metabolism of monoamine oxidase inhibitors. Cell Mol Neurobiol. 1999 Jun;19(3):411-26. Review. Abstract
  3. Meltzer HY, Fang VS, Tricou BJ, Robertson A. Effect of antidepressants on neuroendocrine axis in humans. Adv Biochem Psychopharmacol. 1982;32:303-16. Abstract
  4. Segal M, Heys RF. Inappropriate lactation. Br Med J. 1969 Oct 25;4(5677):236. No abstract available. Abstract

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