Last update June 23, 2022

Periciazine; Pericyazine

Decreased level of risk

New scientific evidences have driven the Apilam staff to update the level of risk associated to this product.
Former level of risk, which was Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment., is now set to Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Level of risk reviewed on June 23, 2022

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Typical, first-generation antipsychotic. Periciazine, metabolite of propericiazine,  is a phenothiazine derivative with general properties similar to those of chlorpromazine. It is used in the treatment of schizophrenia, bipolar disorder, disturbed behaviour and severe anxiety. Oral administration two times a day.

It is excreted in breast milk in a clinically insignificant amount. (Saito 2022)

There are very few bibiographical references of this product.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Parikh 2014), especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Periciazine; Pericyazine is also known as


Periciazine; Pericyazine in other languages or writings:

Groups

Periciazine; Pericyazine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Periciazine; Pericyazine in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 366 daltons
pKa 15.18 -
Theoretical Dose 0.000045 mg/Kg/d
Relative Dose 0.027 %

References

  1. Saito J, Tachibana Y, Wada YS, Yakuwa N, Kawasaki H, Suzuki T, Sago H, Yamatani A, Murashima A. Transfer of brotizolam, periciazine, and sulpiride in cord blood and breast milk, and alprazolam in breast milk: a case report. J Pharm Health Care Sci. 2022 Apr 1;8(1):10. Consulted on May 24, 2022 Abstract Full text (link to original source)
  2. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract

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