Last update June 29, 2022

N06AX05

Compatible

Safe substance and/or breastfeeding is the best option.

Antidepressant Oral administration one to two times daily.

It is excreted into breast milk in clinically non-significant amount. (Saito 2021, Misri 2006, Verbeeck 1986)

Not effects on the infant's physical and psychomotor development at both short or long-term were found. (Saito 2021, Newport 2009, Misri 2006 y 1991)

Variable levels of Prolactin secretion (increment or lowering), which were non-significant, were found after the use of Trazodone (Otani 1995, Roccatagliata 1982 y 1979, Rolandi 1981, Mazzi 1979) . Trazodone can cause galactorrhea. (Arslan 2015)

Expert authors consider the use of this medication possible during breastfeeding. (Hale, LactMed, Uguz 2021)

Because there is less experience published than with other drugs of the same pharmacological group, it should be preferred the use of an alternative drug that is known to be safer in the neonatal period or prematurity.


See below the information of this related product:

  • Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

N06AX05 is Trazodone Hydrochloride in ATC Code/s.

Is written in other languages:

Groups

N06AX05 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing N06AX05 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 63 - 91 %
Molecular weight 408 daltons
Protein Binding 89 - 95 %
VD 0.84 ± 0.16 l/Kg
pKa 7.09 -
Tmax 0.5 - 2 hours
T½ 5 - 13 hours
M/P ratio 0.2 -
Theoretical Dose 0.006 - 0.017 mg/Kg/d
Relative Dose 0.1 - 0.96 %

References

  1. Saito J, Ishii M, Mito A, Yakuwa N, Kawasaki H, Tachibana Y, Suzuki T, Yamatani A, Sago H, Murashima A. Trazodone Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum. Breastfeed Med. 2021 Nov;16(11):922-925. Abstract
  2. Uguz F. A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation. Am J Ther. 2021 Jan-Feb 01;28(1):e118-e126. Abstract
  3. Saito J, Ishii M, Mito A, Yakuwa N, Kawasaki H, Tachibana Y, Suzuki T, Yamatani A, Sago H, Murashima A. Etizolam levels in maternal serum, cord blood, and breast milk during pregnancy and lactation: A case report. Psychiatry Clin Neurosci. 2021 Jun;75(6):211-212. Abstract
  4. Arslan FC, Uysal EK, Ozkorumak E, Tiryaki A. Trazodone induced galactorrhea: a case report. Gen Hosp Psychiatry. 2015 Jul-Aug;37(4):373.e1-2. Abstract
  5. Angelini. Trazodona. Ficha técnica. 2012 Full text (in our servers)
  6. Davanzo R, Copertino M, De Cunto A, Minen F, Amaddeo A. Antidepressant drugs and breastfeeding: a review of the literature. Breastfeed Med. 2011 Abstract
  7. LaboPharm. Trazodone. Drug Summary. 2010 Full text (in our servers)
  8. Newport DJ, Ritchie JC, Knight BT, Glover BA, Zach EB, Stowe ZN. Venlafaxine in human breast milk and nursing infant plasma: determination of exposure. J Clin Psychiatry. 2009 Abstract
  9. Misri S, Corral M, Wardrop AA, Kendrick K. Quetiapine augmentation in lactation: a series of case reports. J Clin Psychopharmacol. 2006 Oct;26(5):508-11. Abstract
  10. Otani K, Yasui N, Kaneko S, Ishida M, Ohkubo T, Osanai T, Sugawara K, Fukushima Y. Trazodone treatment increases plasma prolactin concentrations in depressed patients. Int Clin Psychopharmacol. 1995 Abstract
  11. Misri S, Sivertz K. Tricyclic drugs in pregnancy and lactation: a preliminary report. Int J Psychiatry Med. 1991 Abstract
  12. Verbeeck RK, Ross SG, McKenna EA. Excretion of trazodone in breast milk. Br J Clin Pharmacol. 1986 Abstract Full text (link to original source) Full text (in our servers)
  13. Roccatagliata G, Murialdo G, Albano C, Giovale M, Zauli C, Polleri A. Neuroendocrinological and clinical data upon trazodone treatment in depressed patients. Neuropsychobiology. 1982 Abstract
  14. Rolandi E, Magnani G, Milesi GM, Barreca T. Effect of a psychoactive drug, trazodone, on prolactin secretion in man. Neuropsychobiology. 1981 Abstract
  15. Mazzi C, Montanini R, Riva LP. [Action of trazodone on the secretion of pituitary hormones. Behavior of prolactin and somatotropin]. Minerva Med. 1979 Abstract
  16. Roccatagliata G, De Cecco L, Rossato P, Albano C. Trazodone intravenously administered and plasma prolactin levels. Int Pharmacopsychiatry. 1979 Abstract

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