Last update June 26, 2022

N05AX15

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Atypical or second-generation antipsychotic indicated for the treatment of schizophrenia and other psychotic disorders. Oral administration once daily.

Since the last update, we have not found any published data on its excretion in breastmilk.

Its high percentage of protein binding make it highly unlikely that significant quantities will pass into breast milk.

Cariprazine and its two active metabolites have a very long half-life (2 days, 3 weeks), which could favor the passage into breast milk.

Cariprazine produces minimal effects on prolactin levels. (Culpepper 2022)

Until there is further published data on this drug in relation to breastfeeding, known safer alternatives are preferable (Wichniak 2021), especially during the neonatal period and in cases of prematurity.


See below the information of this related product:

Alternatives

  • Olanzapine (Safe product and/or breastfeeding is the best option.)
  • Paliperidone (Safe product and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe product and/or breastfeeding is the best option.)
  • Risperidone (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

N05AX15 is Cariprazine Hydrochloride in ATC Code/s.

Is written in other languages:

Groups

N05AX15 belongs to these groups or families:

Pharmacokinetics

Variable Value Unit
Molecular weight 464 daltons
Protein Binding 91 - 97 %
pKa 15.68 -
Tmax 3.6 (metab: 6 - 18) hours
31 - 68. (metab: 30 - 446) hours

References

  1. Culpepper L, Vieta E, Kelly DL, Patel MD, Szatmári B, Hankinson A, Earley WR. Minimal Effects of Cariprazine on Prolactin Levels in Bipolar Disorder and Schizophrenia. Neuropsychiatr Dis Treat. 2022 May 12;18:995-1011. Consulted on June 26, 2022 Abstract
  2. Wichniak A, Siwek M, Rymaszewska J, Janas-Kozik M, Wolańczyk T, Bieńkowski P, Dudek D, Heitzman J, Szulc A, Samochowiec J. The position statement of the Working Group of the Polish Psychiatric Association on the use of D2/D3 dopamine receptor partial agonists in special populations. Psychiatr Pol. 2021 Oct 31;55(5):967-987. Abstract Full text (link to original source) Full text (in our servers)

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