Last update July 5, 2022
Tetracyclic antidepressant with marked sedative action. Inhibits norepinephrine reuptake.
Single nightly dose oral administration.
It is excreted in human milk in a clinically insignificant amount and the plasma or urine levels of infants whose mothers took it were either very low or below the limit of detection. (Buist 1993)
It is not recommended to share a bed with the baby if this drug is being taken. (UNICEF 2018, 2017, 2014 and 2013, Landa 2012, ABM 2008, UNICEF 2006)
Due to the sedative action on the mother and because there is less published experience than with other antidepressant drugs, known safer alternatives might be preferable, especially during the neonatal period and in the event of prematurity.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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