クロミプラミン塩酸塩

It is a tricyclic antidepressant with actions and uses similar to those of amitriptyline. It has marked antimuscarinic and sedative properties. It is used in the treatment of depression and obsessive-compulsive disorder. Oral administration in one or two daily doses.

Excreted into breast milk in a clinically non-significant amount ^{(Khachman 2009, Yoshida 1997, Schimmell 1991)} with no problems observed in breastfed infants from treated mothers. ^{(Khachman 2009, Nulman 2002, Birnbaum 1999, Yoshida 1997, Wisner 1995, Schimmell 1991, Misri 1991)}

Levels found in the plasma of those infants were very low or undetectable. ^{(Khachman 2009, Birnbaum 1999, Yoshida 1997, Wisner 1995, Schimmell 1991)}

Because of a tiny excretion into the milk, symptoms due to deprivation syndrome would not be avoided by breastfeeding the infants whose mothers were taking this medication during pregnancy. ^{(ter Horst 2012, Khachman 2009)}

Galactorrhea and increased plasma prolactin levels have been reported. ^{(Cordes 2011, Egberts 1997, Fowlie 1987)}

Known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity. ^{(Sriraman 2015, Gentile 2014, Davanzo 2011, Weissman 2004, Gjerdingen 2003)}

List of WHO essential medicines: compatible with breastfeeding. ^{(WHO-UNICEF 2002)}

Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning. ^{(Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012)}

See below the information of this related product:

• Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)