Last update Dec. 30, 2021
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Хлорфенамина Малеат is Chlorphenamine Maleate in Cyrillic.
Is written in other languages:Хлорфенамина Малеат is also known as
Хлорфенамина Малеат belongs to this group or family:
Main tradenames from several countries containing Хлорфенамина Малеат in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 25 - 50 | % |
Molecular weight | 391 | daltons |
Protein Binding | 72 | % |
VD | 6 - 12 | l/Kg |
pKa | 9.2 | - |
Tmax | 2.5 - 6 | hours |
T½ | 12 - 25 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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First generation antihistaminic and alchylamine drug, with sedative effect. Its active isomer is Dexchlorfeniramine. Oral dosage every 4-6 hours
Since the last update we have not found published data on its excretion in breast milk.
No problems requiring medical attention have been observed in infants of mothers taking chlorpheniramine. (Ito 1993, Paton 1985)
Likely inhibition of lactation within the first weeks post delivery because anti-prolactin effect (WHO 2002, Messinis 1985)
Short-term and low dose (2 mg one or twice-day) treatment is compatible with breastfeeding.(LactMed)
Follow-up for sedation and feeding ability of the infant. (Butler 2014, WHO 2002)
For long-term treatment an alternative drug should be preferred. (Powell 2007)
Compounds in association with expectorants, corticoids and cough relief medicines are available. Avoid drug associations especially while breastfeeding.
Bed-sharing is not recommended for mothers who are taking this medication. (UNICEF 2013, Landa 2012, ABM 2008, UNICEF 2006).
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