Last update June 17, 2021

Chlorphenamine Maleate

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

First generation antihistaminic and alchylamine drug, with sedative effect. Its active isomer is Dexchlorfeniramine.
Oral dosage every 4-6 hours

Since the last update we have not found published data on its excretion in breast milk.

No problems requiring medical attention have been observed in infants of mothers taking chlorpheniramine (Ito 1993, Paton 1985).

Likely inhibition of lactation within the first weeks post delivery because anti-prolactin effect (WHO 2002, Messinis 1985).

Short-term and low dose (2 mg one or twice-day) treatment is compatible with breastfeeding (Lactmed).
Follow-up for sedation and feeding ability of the infant (Butler 2014, WHO 2002).
For long-term treatment an alternative drug should be preferred (Powell 2007).

Compounds in association with expectorants, corticoids and cough relief medicines are available. Avoid drug associations especially while breastfeeding.

Bed-sharing is not recommended for mothers who are taking this medication (UNICEF 2013, Landa 2012, ABM 2008, UNICEF 2006).


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

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Other names

Chlorphenamine Maleate is also known as


Chlorphenamine Maleate in other languages or writings:

Group

Chlorphenamine Maleate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Chlorphenamine Maleate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 - 50 %
Molecular weight 391 daltons
Protein Binding 72 %
VD 6 - 12 l/Kg
pKa 9,2 -
Tmax 2,5 - 6 hours
T1/2 12 - 25 hours

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