Last update Aug. 30, 2021


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Indicated in the treatment and prevention of arterial, venous or pulmonary thromboembolism and in acute coronary syndrome.
Authorized use in neonates and infants.
Intravenous, intraarterial or subcutaneous administration.

At the date of the last update, there was no available published data on its excretion in breast milk.

The high molecular weight of standard or unfractionated heparin and also of low molecular weight heparins makes their passage into breast milk in clinically significant amounts highly unlikely (Pfizer2016); manufacturers claim that it is not excreted in breast milk (AEMPS 2017, Hospira 2014).

In addition, heparins are inactivated in the gastrointestinal tract, not being absorbed (practically zero oral bioavailability), which prevents the passage into plasma of the infant from ingested breast milk (Pfizer2016).

There has been virtually no excretion in breast milk of other lower molecular weight heparins such as dalteparin (Richter 2001). There is absence of anticoagulant activity in plasma of infants breastfed by mothers treated with enoxaparin (Guillonneau 1996).

The risk of heparin-induced thrombocytopenia and osteoporosis is lower with low molecular weight heparins (Fuller 2013, Middeldorp 2011, Rath 2010).

Various medical societies, experts, and expert consensus consider the use of this medication safe during breastfeeding (Hale, Lactmed, Bates 2018 and 1997, Briggs 2015, Schaefer 2015, Rowe 2013, Fuller 2013, Yurdakök 2012, Rath 2010).

WHO 2002 Essential Medicines List: compatible with breastfeeding (WHO 2002).


  • Acenocoumarol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Dalteparin Sodium ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Enoxaparin Sodium ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Warfarin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

ヘパリン is Heparin in Japanese.

Is written in other languages:

ヘパリン is also known as


ヘパリン belongs to this group or family:


Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 15.000 (3.000 - 30.000) daltons
Protein Binding 95 %
VD 0,07 l/Kg
Tmax 0,3 hours
T1/2 1,5 (1 - 6) hours
M/P ratio 0 -

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