Last update Oct. 9, 2016


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Its high plasma protein-binding capacity would explain the very low excretion observed into breast milk (Houwert-de Jong 1981, Nava 2004).

No clinical side-effects and/or blood test disarrangements were observed in infants whose mothers were treated with acenocoumarol (Houwert-de Jong 1981, Fondevila 1989).


We do not have alternatives for Acenocoumarol since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Acenocoumarol is also known as

Acenocoumarol in other languages or writings:


Acenocoumarol belongs to this group or family:


Main tradenames from several countries containing Acenocoumarol in its composition:


Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 353 daltons
Protein Binding 99 %
Tmax 1 - 3 hours
T1/2 8 - 11 hours
Theoretical Dose 0.002 mg/Kg/d
Relative Dose 1 %


  1. Bates SM, Rajasekhar A, Middeldorp S, McLintock C, Rodger MA, James AH, Vazquez SR, Greer IA, Riva JJ, Bhatt M, Schwab N, Barrett D, LaHaye A, Rochwerg B. American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy. Blood Adv. 2018 Nov 27;2(22):3317-3359. Abstract Full text (link to original source)
  2. Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO; American College of Chest Physicians. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e691S-e736S. Abstract Full text (link to original source) Full text (in our servers)
  3. Middeldorp S. How I treat pregnancy-related venous thromboembolism. Blood. 2011 Abstract Full text (link to original source) Full text (in our servers)
  4. Nava LE, Gómez AB, González VM. [Plasma and milk concentrations of acenocoumarin in breast-feeding women during post partum]. Ginecol Obstet Mex. 2004 Abstract
  5. Bates SM, Ginsberg JS. Anticoagulants in pregnancy: fetal effects. Baillieres Clin Obstet Gynaecol. 1997 Abstract
  6. Olthof E, de Vries TW. [Breast feeding and oral anticoagulants]. Tijdschr Kindergeneeskd. 1993 Abstract
  7. Fondevila CG, Meschengieser S, Blanco A, Peñalva L, Lazzari MA. Effect of acenocoumarine on the breast-fed infant. Thromb Res. 1989 Abstract
  8. Houwert-de Jong M, Gerards LJ, Tetteroo-Tempelman CA, de Wolff FA. May mothers taking acenocoumarol breast feed their infants? Eur J Clin Pharmacol. 1981 Abstract

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e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) of Mexico

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