Last update Oct. 12, 2022

فينيلبروبانولامين

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

It is a sympathomimetic with an action similar to ephedrine, used in products such as nasal decongestant and for weight loss. Oral administration twice daily.

On latest update relevant data on breastfeeding was not found.

Pharmacokinetic data indicates that drug excretion into breast milk may occur.

Appears as part of many compounds for cough relief, mucolytics, expectorants and nose decongestants. Single drug (one active principle only) medicines should be preferred mostly while breastfeeding.

Withheld from marketing in many countries because of hypertension and severe side effects. FDA withdrew it due to safety risks and lack of efficacy.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives are preferable, especially during the neonatal period and in case of prematurity.

There is good quality evidence that exclusive breastfeeding helps to regain pre-pregnancy weight earlier than if breastfeeding is partial (mixed) or there is no breastfeeding, and that prolonged breastfeeding helps maintain that loss and as well as body fat loss.(Jayasinghe 2021, Schalla 2017, López 2016, Jarlenski 2014, Sámano 2013, Neville 2014, Hatsu 2008, Dewey 2004, 2001 y 1993, Kramer 1993)

Alternatives

  • Cetirizine Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Desloratadine (Safe substance and/or breastfeeding is the best option.)
  • Hypocaloric Diet (Safe substance and/or breastfeeding is the best option.)
  • Liraglutide (Safe substance and/or breastfeeding is the best option.)
  • Maternal Sport (Safe substance and/or breastfeeding is the best option.)
  • Orlistat (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Pseudoephedrine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

فينيلبروبانولامين is Phenylpropanolamine; Phenylpropanolamine Hydrochloride in Arabic.

Is written in other languages:

فينيلبروبانولامين is also known as

Groups

فينيلبروبانولامين belongs to these groups or families:

Tradenames

Main tradenames from several countries containing فينيلبروبانولامين in its composition:

  • Actidue
  • Actifed (India)™. Contains other elements than فينيلبروبانولامين in its composition
  • Actiflu™. Contains other elements than فينيلبروبانولامين in its composition
  • Afebrin™. Contains other elements than فينيلبروبانولامين in its composition
  • Antiadipositum
  • Basoplex™. Contains other elements than فينيلبروبانولامين in its composition
  • Boxogetten S
  • Calgayan™. Contains other elements than فينيلبروبانولامين in its composition
  • Colcaps
  • Contac™. Contains other elements than فينيلبروبانولامين in its composition
  • Day & Night™. Contains other elements than فينيلبروبانولامين in its composition
  • Dimetapp™. Contains other elements than فينيلبروبانولامين in its composition
  • Dimetapp Expectorante (Brazil)™. Contains other elements than فينيلبروبانولامين in its composition
  • Irritos™. Contains other elements than فينيلبروبانولامين in its composition
  • Kontexin
  • Lentostamin™. Contains other elements than فينيلبروبانولامين in its composition
  • Nasomixin
  • Neo-Diophen™. Contains other elements than فينيلبروبانولامين in its composition
  • Numonyl Jarabe™. Contains other elements than فينيلبروبانولامين in its composition
  • Ornade-2
  • Rhinopront™. Contains other elements than فينيلبروبانولامين in its composition
  • Rinexin
  • Rinogan™. Contains other elements than فينيلبروبانولامين in its composition
  • Rinomar (Finland, Sweden)™. Contains other elements than فينيلبروبانولامين in its composition
  • Senioral
  • Slim Caps
  • Triaminic

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 38 %
Molecular weight 188 daltons
Protein Binding Low / Bajo %
VD 4.5 l/Kg
pKa 13.9 -
Tmax 0.5 - 2 hours
3.8 - 4.3 hours

References

  1. Jayasinghe S, Herath MP, Beckett JM, Ahuja KDK, Byrne NM, Hills AP. Exclusivity of breastfeeding and body composition: learnings from the Baby-bod study. Int Breastfeed J. 2021 May 19;16(1):41. Abstract Full text (link to original source)
  2. Schalla SC, Witcomb GL, Haycraft E. Body Shape and Weight Loss as Motivators for Breastfeeding Initiation and Continuation. Int J Environ Res Public Health. 2017 Jul 11;14(7). pii: E754. Abstract Full text (link to original source)
  3. López-Olmedo N, Hernández-Cordero S, Neufeld LM, García-Guerra A, Mejía-Rodríguez F, Méndez Gómez-Humarán I. The Associations of Maternal Weight Change with Breastfeeding, Diet and Physical Activity During the Postpartum Period. Matern Child Health J. 2016 Feb;20(2):270-80. Abstract
  4. Jarlenski MP, Bennett WL, Bleich SN, Barry CL, Stuart EA. Effects of breastfeeding on postpartum weight loss among U.S. women. Prev Med. 2014 Dec;69:146-50. Abstract Full text (link to original source)
  5. Neville CE, McKinley MC, Holmes VA, Spence D, Woodside JV. The relationship between breastfeeding and postpartum weight change--a systematic review and critical evaluation. Int J Obes (Lond). 2014 Apr;38(4):577-90. Abstract
  6. Sámano R, Martínez-Rojano H, Godínez Martínez E, Sánchez Jiménez B, Villeda Rodríguez GP, Pérez Zamora J, Casanueva E. Effects of breastfeeding on weight loss and recovery of pregestational weight in adolescent and adult mothers. Food Nutr Bull. 2013 Jun;34(2):123-30. Abstract
  7. Hatsu IE, McDougald DM, Anderson AK. Effect of infant feeding on maternal body composition. Int Breastfeed J. 2008 Aug 6;3:18. Abstract Full text (link to original source)
  8. Dewey KG. Impact of breastfeeding on maternal nutritional status. Adv Exp Med Biol. 2004;554:91-100. Review. Abstract
  9. Dewey KG, Cohen RJ, Brown KH, Rivera LL. Effects of exclusive breastfeeding for four versus six months on maternal nutritional status and infant motor development: results of two randomized trials in Honduras. J Nutr. 2001 Feb;131(2):262-7. Abstract Full text (link to original source) Full text (in our servers)
  10. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  11. Dewey KG, Heinig MJ, Nommsen LA. Maternal weight-loss patterns during prolonged lactation. Am J Clin Nutr. 1993 Aug;58(2):162-6. Abstract
  12. Kramer FM, Stunkard AJ, Marshall KA, McKinney S, Liebschutz J. Breast-feeding reduces maternal lower-body fat. J Am Diet Assoc. 1993 Apr;93(4):429-33. Abstract
  13. Kanfer I, Dowse R, Vuma V. Pharmacokinetics of oral decongestants. Pharmacotherapy. 1993 Abstract
  14. Scherzinger SS, Dowse R, Kanfer I. Steady state pharmacokinetics and dose-proportionality of phenylpropanolamine in healthy subjects. J Clin Pharmacol. 1990 Abstract
  15. Kristiansson B, Abdul Ghani N, Eriksson M, Garle M, Qirbi A. Use of khat in lactating women: a pilot study on breast-milk secretion. J Ethnopharmacol. 1987 Abstract

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