Last update Feb. 7, 2022

Dyphylline

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Bronchodilator derived from theophylline and with less activity than this. Indicated in the treatment of asthma. Oral administration every 6 hours or intramuscularly.

It is excreted in breast milk in an amount that could be clinically significant, since the infant can receive, through breast milk, up to a quarter of the usual pediatric dose. (Jarboe 1981)

American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)

Monitor the appearance of irritability or insomnia in the infant.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Albuterol (Safe substance and/or breastfeeding is the best option.)
  • Aminophylline (Safe substance and/or breastfeeding is the best option.)
  • Terbutaline Sulfate (Safe substance and/or breastfeeding is the best option.)
  • Theophylline (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Dyphylline is also known as Diprophylline. Here it is a list of alternative known names::


Dyphylline in other languages or writings:

Group

Dyphylline belongs to this group or family:

Tradenames

Main tradenames from several countries containing Dyphylline in its composition:

List of 7 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 254 daltons
Protein Binding 84 %
VD 0.5 l/Kg
pKa 13.91 -
Tmax 2 - 4 hours
T½ 3.2 ± 0.76 hours
M/P ratio 2.1 -
Theoretical Dose 2. 4 - 3.64 mg/Kg/d
Relative Dose 48 - 72 %
Ped.Relat.Dose 17.1 - 26 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Stablein JJ, Samaan SS, Bukantz SC, Lockey RF. Pharmacokinetics and bioavailability of three dyphylline preparations. Eur J Clin Pharmacol. 1983;25(2):281-3. Abstract
  3. Jarboe CH, Cook LN, Malesic I, Fleischaker J. Dyphylline elimination kinetics in lactating women: blood to milk transfer. J Clin Pharmacol. 1981 Oct;21(10):405-10. Abstract

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