Last update Feb. 7, 2022
Very Low Risk
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Aminophylline is also known as
Aminophylline in other languages or writings:
Aminophylline belongs to this group or family:
Main tradenames from several countries containing Aminophylline in its composition:
|Protein Binding||40 - 65||%|
|VD||0.45 (0.3 - 0.7)||l/Kg|
|T½||7 - 9||hours|
|M/P ratio||0.5 - 1.1||-|
|Theoretical Dose||0.4 - 1||mg/Kg/d|
|Relative Dose||5 - 11||%|
|Ped.Relat.Dose||3.5 - 8.3||%|
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Aminophylline is a combination of theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and performs its bronchodilator action. Intravenous or oral administration in two daily doses.
Theophylline is excreted in human milk in small amounts but it could be clinically significant (Gardner 1987, Reinhardt 1983, Stec 1980, Yurchak 1976).
Except in the case of a newborn who developed irritability and difficulties falling asleep, no problems have been observed in infants whose mothers mothers treated with theophylline (Yurchak 1976).
Maternal theophylline serum levels must be monitored and maintained at 5 - 12 mcg / mL (National Asthma 2004).
Several medical societies, experts and expert consensus, consider the use of this medication to be compatible during breastfeeding. ((Middleton 2020, National Asthma Ed. 2004)
American Academy of Pediatrics: theophylline is usually compatible with breastfeeding (AAP 2001).
List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002).
Monitor the appearance of irritability or insomnia in the infant.
Known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.
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