Last update June 18, 2022

ドスレピン塩酸塩

Compatible

Safe substance and/or breastfeeding is the best option.

It is excreted into breastmilk in a clinically non-significant amount. (Yoshida 1997, Ilett 1992, Rees 1976)

Plasma levels in the infant have been found very low. (Yoshida 1997, Ilett 1992)

No side effects have been observed in infants of mothers treated with dothiepin. (Yoshida 1997, Buist 1995, Ilett 1992)

Dothiepin can produce galactorrhea and hyperprolactinemia. (Gadd 1987)

Expert authors consider the use of this medication safe during lactation (LactMed, Hale, Wisner 1996). Some authors consider other alternatives to be safer during the neonatal period and in case of prematurity. (Weissman 2004)

Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning. (Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012)

 


See below the information of this related product:

  • Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

ドスレピン塩酸塩 is Dosulepin Hydrochloride in Japanese.

Is written in other languages:

ドスレピン塩酸塩 is also known as

Groups

ドスレピン塩酸塩 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing ドスレピン塩酸塩 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 %
Molecular weight 332 daltons
Tmax 3 hours
T½ 60 hours
M/P ratio 1.2 - 4.5 -
Theoretical Dose 0.008 mg/Kg/d
Relative Dose 0.64 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Grzeskowiak LE, Leggett C, Costi L, Roberts CT, Amir LH. Impact of serotonin reuptake inhibitor use on breast milk supply in mothers of preterm infants: a retrospective cohort study. Br J Clin Pharmacol. 2018 Jun;84(6):1373-1379. Abstract Full text (link to original source)
  4. Leggett C, Costi L, Morrison JL, Clifton VL, Grzeskowiak LE. Antidepressant Use in Late Gestation and Breastfeeding Rates at Discharge from Hospital. J Hum Lact. 2017 Nov;33(4):701-709. Abstract
  5. Venkatesh KK, Castro VM, Perlis RH, Kaimal AJ. Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study. J Perinatol. 2017 Sep;37(9):1003-1009. Abstract
  6. Gorman JR, Kao K, Chambers CD. Breastfeeding among women exposed to antidepressants during pregnancy. J Hum Lact. 2012 Abstract
  7. Weissman AM, Levy BT, Hartz AJ, Bentler S, Donohue M, Ellingrod VL, Wisner KL. Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants. Am J Psychiatry. 2004 Abstract Full text (link to original source) Full text (in our servers)
  8. Wisner KL, Perel JM, Findling RL. Antidepressant treatment during breast-feeding. Am J Psychiatry. 1996 Sep;153(9):1132-7. Review. Abstract
  9. Buist A, Janson H. Effect of exposure to dothiepin and northiaden in breast milk on child development. Br J Psychiatry. 1995 Sep;167(3):370-3. Abstract
  10. Ilett KF, Lebedevs TH, Wojnar-Horton RE, Yapp P, Roberts MJ, Dusci LJ, Hackett LP. The excretion of dothiepin and its primary metabolites in breast milk. Br J Clin Pharmacol. 1992 Jun;33(6):635-9. Abstract
  11. Gadd EM, Norris CM, Beeley L. Antidepressants and galactorrhoea. Int Clin Psychopharmacol. 1987 Oct;2(4):361-3. Abstract
  12. Rees JC, Glass RC, Sporne GA. Serum and breast milk concentration of dothiepin. Practitioner. 1976;217:686. (Cit. Hale)

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