Last update Aug. 29, 2021

Curling Factor

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Antifungal used in dermatophyte infection.
Oral administration (tinea capitis and ringworm of the nails) or topical (tinea pedis).
Authorized use in Pediatrics (Chen 2016) from two years of age.

At the date of the last update, there was no available published data on its excretion in breast milk.

Its high fixation to plasma proteins makes it difficult to pass into breast milk in a clinically significant amount, but its high fat solubility (Mactal 2001) would facilitate it.

Until more published data on this drug in relation to breastfeeding is known, known safer alternatives (Chen 2016) may be preferable (Butler 2013), especially during the neonatal period and in the case of prematurity.

Alternatives

  • Fluconazole ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Itraconazole ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Terbinafine (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Curling Factor is also known as Griseofulvin.


Curling Factor in other languages or writings:

Groups

Curling Factor belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Curling Factor in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 - 70 %
Molecular weight 353 daltons
Protein Binding 84 %
pKa 17.7 -
Tmax 4 - 8 hours
T½ 9 - 21 hours

References

  1. Chen X, Jiang X, Yang M, González U, Lin X, Hua X, Xue S, Zhang M, Bennett C. Systemic antifungal therapy for tinea capitis in children. Cochrane Database Syst Rev. 2016 May 12;(5):CD004685. Abstract
  2. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  4. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  5. Lin C, Symchowicz S. Absorption, distribution, metabolism, and excretion of griseofulvin in man and animals. Drug Metab Rev. 1975;4(1):75-95. Review. No abstract available. Abstract

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