Last update June 4, 2016


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Pharmacokinetic data (moderately high molecular weight and high protein binding capacity) explain its nil or negligible amount observed in breast milk (McNamara, 2004), such that a breastfed infant would receive a maximum of 35 micrograms per day of Itraconazole, amount which is a hundred times lower than the pediatric dose of 5 mg / kg / day currently recommended (Janssen Cazzaniga 2014 and 1996)

Both, low oral bioavailability and alkaline pH hinder its absorption from ingested milk.

It is used to treat fungal infections in children, including premature babies, with a good tolerance.

Itraconazole significantly increases plasma concentrations of Domperidone, which must be taken into account in case of simultaneous administration of both drugs.


We do not have alternatives for Itraconazole since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Itraconazole is also known as

Itraconazole in other languages or writings:


Itraconazole belongs to this group or family:


Main tradenames from several countries containing Itraconazole in its composition:


Variable Value Unit
Oral Bioavail. 55 %
Molecular weight 706 daltons
Protein Binding 99.8 %
VD 10 l/Kg
Tmax 4 hours
64 hours
M/P ratio 0.5 - 1.8 -
Theoretical Dose 0.01 mg/Kg/d
Relative Dose 0.3 %
Ped.Relat.Dose 0.2 - 0.3 %


  1. Mahamaytakit N, Singalavanija S, Limpongsanurak W. Subcutaneous zygomycosis in children: 2 case reports. J Med Assoc Thai. 2014 Abstract
  2. Janssen. Itraconazole. Sporanox Data Sheet. 2014 Full text (in our servers)
  3. Gupta AK, Paquet M. Systemic antifungals to treat onychomycosis in children: a systematic review. Pediatr Dermatol. 2013 Abstract
  4. Yoshizato T, Kotegawa T, Imai H, Tsutsumi K, Imanaga J, Ohyama T, Ohashi K. Itraconazole and domperidone: a placebo-controlled drug interaction study. Eur J Clin Pharmacol. 2012 Abstract
  5. McNamara PJ, Abbassi M. Neonatal exposure to drugs in breast milk. Pharm Res. 2004 Abstract
  6. Gupta AK, Cooper EA, Ginter G. Efficacy and safety of itraconazole use in children. Dermatol Clin. 2003 Abstract
  7. AEMPS. Itraconazol. Ficha técnica. 2003 Full text (in our servers)
  8. EK Cazzaniga and A Chanlam. Personal communication (in Drugs in Pregnancy and Lactation, G. Briggs. Access on line, 2016). Janssen Pharmaceuticals. 1996
  9. Bhandari V, Narang A. Oral itraconazole therapy for disseminated candidiasis in low birth weight infants. J Pediatr. 1992 Abstract
  10. Dhondt F, Ninane J, De Beule K, Dhondt A, Cauwenbergh G. Oral candidosis: treatment with absorbable and non-absorbable antifungal agents in children. Mycoses. 1992 Abstract

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