Last update April 5, 2025

Итраконазол

Compatible

Safe product and/or breastfeeding is the best option.

It is a triazole antifungal used in the treatment of oropharyngeal and vulvovaginal candidiasis, pityriasis versicolor, other dermatophytosis, onychomycosis and systemic fungal infections and some protozoal infections, such as Acanthamoeba keratitis, leishmaniasis and trypanosomiasis. Oral administration.

Its pharmacokinetic data (moderately high molecular weight and high percentage of protein binding) explain the no or minimal passage into milk observed (McNamara 2004), such that a breastfed infant would receive a maximum of 35 micrograms of itraconazole daily, hundreds of times less than the paediatric dose of 5 mg/kg/day. (Briggs 2015, Janssen 2014, Cazzaniga 1996)

In addition, its low oral bioavailability and the alkaline environment of milk hinder its absorption.

It is used for the treatment of fungal infections in children, including premature infants, with good tolerance. (Mahamaytakit 2014, Gupta 2013 and 2003, Dhondt 1992, Bhandari 1992)

Itraconazole significantly increases plasma concentrations of domperidone, which has to be taken into account in case of simultaneous administration of both drugs. (Yoshizato 2012)

Alternatives

We do not have alternatives for Итраконазол since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Итраконазол is Itraconazole in Cyrillic.

Is written in other languages:

Итраконазол is also known as

Group

Итраконазол belongs to this group or family:

Tradenames

Main tradenames from several countries containing Итраконазол in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 55 %
Molecular weight 706 daltons
Protein Binding 99.8 %
VD 10 l/Kg
Tmax 4 hours
64 hours
M/P ratio 0.5 - 1.8 -
Theoretical Dose 0.01 mg/Kg/d
Relative Dose 0.3 %
Ped.Relat.Dose 0.2 - 0.3 %

References

  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  2. Mahamaytakit N, Singalavanija S, Limpongsanurak W. Subcutaneous zygomycosis in children: 2 case reports. J Med Assoc Thai. 2014 Abstract
  3. Janssen. Itraconazole. Sporanox Data Sheet. 2014 Full text (in our servers)
  4. Gupta AK, Paquet M. Systemic antifungals to treat onychomycosis in children: a systematic review. Pediatr Dermatol. 2013 Abstract
  5. Yoshizato T, Kotegawa T, Imai H, Tsutsumi K, Imanaga J, Ohyama T, Ohashi K. Itraconazole and domperidone: a placebo-controlled drug interaction study. Eur J Clin Pharmacol. 2012 Abstract
  6. McNamara PJ, Abbassi M. Neonatal exposure to drugs in breast milk. Pharm Res. 2004 Abstract
  7. AEMPS. Itraconazol. Ficha técnica. 2003 Full text (in our servers)
  8. Gupta AK, Cooper EA, Ginter G. Efficacy and safety of itraconazole use in children. Dermatol Clin. 2003 Abstract
  9. EK Cazzaniga and A Chanlam. Personal communication (in Drugs in Pregnancy and Lactation, G. Briggs. Access on line, 2016). Janssen Pharmaceuticals. 1996
  10. Bhandari V, Narang A. Oral itraconazole therapy for disseminated candidiasis in low birth weight infants. J Pediatr. 1992 Abstract
  11. Dhondt F, Ninane J, De Beule K, Dhondt A, Cauwenbergh G. Oral candidosis: treatment with absorbable and non-absorbable antifungal agents in children. Mycoses. 1992 Abstract

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