Last update Jan. 6, 2022

Clobenzorex Hydrochloride

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Psychostimulant precursor to amphetamine that is metabolized in the body to amphetamine (Cody 2002 and 2001) used as an anti-obesity medication. It can cause insomnia, anorexia, nervousness, and cardiomyopathy (Montastruc 2010, Cornaert 1986). Oral administration once a day.

Since the last update we have not found any published data on its excretion in breast milk.

The paucity of published pharmacokinetic data does not allow prediction of its excretion in human milk, but its metabolite amphetamine is excreted in human milk.

Due to its negative risk-benefit balance, it has been withdrawn from the market by the main drug agencies (EMA and FDA) of most countries in the world.(Onakpoya 2016, AEMPS 2000)

Breastfeeding women return to pre-pregnancy body weight sooner than bottle-feeding mothers.


See below the information of these related products:

  • Amfetamine (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Dexamfetamine Sulfate (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Alternatives

  • Hypocaloric Diet ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Maternal Sport ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Orlistat (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Clobenzorex Hydrochloride is also known as


Clobenzorex Hydrochloride in other languages or writings:

Group

Clobenzorex Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Clobenzorex Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 296 daltons
Tmax 1 - 1.5 hours

References

  1. Onakpoya IJ, Heneghan CJ, Aronson JK. Post-marketing withdrawal of anti-obesity medicinal products because of adverse drug reactions: a systematic review. BMC Med. 2016 Nov 29;14(1):191. Review. Abstract
  2. Montastruc G, Favreliere S, Sommet A, Pathak A, Lapeyre-Mestre M, Perault-Pochat MC, Montastruc JL; French Association of Regional PharmacoVigilance Centres.. Drugs and dilated cardiomyopathies: A case/noncase study in the French PharmacoVigilance Database. Br J Clin Pharmacol. 2010 Mar;69(3):287-94. Abstract
  3. Cody JT. Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results. J Occup Environ Med. 2002 May;44(5):435-50. Review. Abstract
  4. Cody JT, Valtier S. Amphetamine, clobenzorex, and 4-hydroxyclobenzorex levels following multidose administration of clobenzorex. J Anal Toxicol. 2001 Apr;25(3):158-65. Abstract
  5. AEMPS Retirada del mercado de los medicamentos anorexígenos de acción central. 2000 Full text (in our servers)
  6. Cornaert P, Camblin J, Graux P, Anaye B, Dutoit A, Croccel L. [Congestive cardiomyopathy in addiction to clobenzorex, an anorexigenic drug]. Arch Mal Coeur Vaiss. 1986 Apr;79(4):515-8. French. Abstract

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