Last update Oct. 30, 2023

Amprenavir

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Amprenavir is an antiretroviral, HIV protease inhibitor, with activity against HIV. It is used in the treatment of HIV infection and AIDS. It is used with other aniretrovirals because viral resistance emerges rapidly if it is used as a monodrug. Oral administration.

At the time of the last update, we found no published data on its excretion in breast milk.

Its pharmacokinetic data (very high percentage of protein binding, moderately high molecular weight and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Ampreanvir has been withdrawn from the market in many countries.

"Individuals with HIV who are on antiretroviral treatment (ART) with a sustained undetectable viral load and who choose to breastfeed should be supported in this decision". (Panel 2022 p ix)


See below the information of this related product:

Alternatives

  • Bictegravir (Safe substance and/or breastfeeding is the best option.)
  • Darunavir (DRV) (Safe substance and/or breastfeeding is the best option.)
  • Emtricitabine (FTC) (Safe substance and/or breastfeeding is the best option.)
  • Lamivudine (3TC) (Safe substance and/or breastfeeding is the best option.)
  • Nevirapine (NVP) (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Tenofovir (TAF / TDF) (Safe substance and/or breastfeeding is the best option.)
  • Zidovudine (ZDV / AZT) (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Amprenavir in other languages or writings:

Group

Amprenavir belongs to this group or family:

Tradenames

Main tradenames from several countries containing Amprenavir in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 506 daltons
Protein Binding 90 %
VD 6 l/Kg
pKa 13.6 -
Tmax 1 - 2 hours
T½ 7.1 - 10.6 hours

References

  1. Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission. Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States. Department of Health and Human Services. 2023 Consulted on June 16, 2023 Abstract Full text (link to original source)
  2. EMEA Amprenavir Fiche técnica 2009 Full text (in our servers)
  3. EMEA Amprenavir Data Sheet 2009 Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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