Last update Dec. 21, 2013

Amprenavir

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Anti-HIV drug. No experience in young infants.

Withdrawn from market.

Mothers should be aware of HIV transmission through breast milk has been reported.

Alternatives

  • Lamivudine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Nevirapine (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Tenofovir Disoproxil Fumarate (TDF) ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Zidovudine (ZDV) ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Amprenavir belongs to this group or family:

Tradenames

Main tradenames from several countries containing Amprenavir in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 506 daltons
Protein Binding 90 %
VD 6 l/Kg
Tmax 1 - 2 hours
T1/2 7,1 - 10,6 hours

References

  1. EMEA Amprenavir Fiche técnica 2009 Full text (in our servers)
  2. EMEA Amprenavir Data Sheet 2009 Full text (in our servers)

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