Last update: June 9, 2018


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Enalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of high blood pressure and heart failure.
Oral administration every 12-24 hours.

It is excreted in breastmilk in clinically insignificant amounts (Anderson 2018, Serrano 2015, Rush 1991, Redman 1990, Kirsten 1998, Huttunen 1989) and no problems have been observed in infants whose mothers were taking it (Anderson 2018, Rush 1991, Huttunen 1989 ), nor problems in the establishment of breastfeeding (Bach 1995).

It use is authorized in small infants and, off-label, in neonates. (FDA 2018, Kirsten 1998)

Due to its possible renal toxicity in preterm infants, it is preferable to avoid its use during the neonatal period in the case of prematurity. (Serrano 2015).

Expert authors and medical associations such as the American Academy of Pediatrics consider it to be a drug which is usually compatible with breastfeeding (Serrano 2015, Rowe 2013, Dennis 2012, Ghanem 2008, AAP 2001, Kirsten 1998).

The protective role of breastfeeding against maternal hypertension has been proven (Park 2018).


We do not have alternatives for 依那普利 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

依那普利 is Enalapril in Chinese.

Is written in other languages:

依那普利 is also known as


依那普利 belongs to this group or family:


Main tradenames from several countries containing 依那普利 in its composition:


Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 492 daltons
Protein Binding 60 %
VD 1,7 l/Kg
pKa 3,67 -
Tmax 1,5 hours
T1/2 11 hours
M/P ratio 0,8 -
Theoretical Dose 0,0009 mg/Kg/d
Relative Dose 0,56 %
Relat.Ped.Dose 0,18 - 0,9 %


  1. Park S, Choi NK. Breastfeeding and Maternal Hypertension. Am J Hypertens. 2018 Abstract
  2. AEMPS. Enalapril. Ficha técnica. 2018 Full text (in our servers)
  3. FDA. Enalapril. Drug Summary. 2018 Full text (in our servers)
  4. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  5. Kearney L, Wright P, Fhadil S, Thomas M. Postpartum Cardiomyopathy and Considerations for Breastfeeding. Card Fail Rev. 2018 Abstract Full text (link to original source) Full text (in our servers)
  6. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  7. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Abstract
  8. Dennis AT. Management of pre-eclampsia: issues for anaesthetists. Anaesthesia. 2012 Sep;67(9):1009-20. Abstract Full text (link to original source) Full text (in our servers)
  9. Ghanem FA, Movahed A. Use of antihypertensive drugs during pregnancy and lactation. Cardiovasc Ther. 2008 Abstract Full text (link to original source) Full text (in our servers)
  10. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  11. Kirsten R, Nelson K, Kirsten D, Heintz B. Clinical pharmacokinetics of vasodilators. Part II. Clin Pharmacokinet. 1998 Abstract
  12. Bach N. [Enalapril treatment of a pre-eclamptic woman]. Ugeskr Laeger. 1995 Abstract
  13. Rush JE, Snyder DL, Barrish A, Hichens M. Comment on Huttunen K, Grönhagen-Riska C and Fyhrquist F, 1989. Enalapril treatment of a nursing mother with slightly impaired renal function. Clin Nephrol 31: 278. Clin Nephrol. 1991 Abstract
  14. Redman CW, Kelly JG, Cooper WD. The excretion of enalapril and enalaprilat in human breast milk. Eur J Clin Pharmacol. 1990 Abstract
  15. Huttunen K, Grönhagen-Riska C, Fyhrquist F. Enalapril treatment of a nursing with slightly impaired renal function. Clin Nephrol. 1989 Abstract

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