Last update: July 21, 2017

Valpromide

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Amide derivative of valproic acid that is metabolized in the liver to valproic acid.
To view the complete bibliography, see entry on valproic acid.

Valproic acid is excreted in breast milk in clinically non-significant amount without problems in the short or long term in infants whose mothers were treated. Plasma levels of these infants were undetectable or very low. Cognitive development did not suffer any alteration.

An infant was presented with thrombocytopenic purpura and anemia who recovered after removing valproate in the mother. However, doubts were raised on whether it was instead a post-viral reaction that led to idiopathic thrombocytopenic purpura.

The administration of valproic acid does not affect prolactin levels.

The American Academy of Pediatrics rates it as usual compatible with breastfeeding medication.
WHO List of Essential Medicines 2002: compatible with breastfeeding.


See below the information of this related product:

Alternatives

We do not have alternatives for Valpromide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Valpromide is also known as


Valpromide in other languages or writings:

Group

Valpromide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Valpromide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 143 daltons
Protein Binding 80 %
Tmax 4 hours
T1/2 20 hours
M/P ratio 0,4 -

References

  1. AEMPS. Valpromida Ficha técnica. 2015 Full text (in our servers)
  2. Bialer M, Rubinstein A, Raz I, Abramsky O. Pharmacokinetics of valpromide after oral administration of a solution and a tablet to healthy volunteers. Eur J Clin Pharmacol. 1984 Abstract

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