Last update: Jan. 15, 2019

Urea

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Urea is the product of degradation of proteins in humans and mammals in general.
It is found naturally in the body, including blood, bile and breastmilk. It is eliminated through urine and sweat.
Its concentration is 10mg/dL in colostrum and 30 mg/dL in mature milk (Lawrence 2016 p 767).
It diffuses passively into breastmilk from blood plasma (Lawrence 2016 p 368).

In medicine it is used in the form of dermatological creams as a moisturizer and, at high concentrations, as a keratolytic.

Since the last update we have not found published data on its excretion in breastmilk.

The small dose and low plasma absorption of most topical dermatological preparations make transfer of significant amounts into breastmilk very unlikely.

Expert authors do not consider it incompatible with breastfeeding (Hale 2017 p 966, Briggs 2017) provided, according to some, it is not applied over large areas of the skin or in occlusive dressings that could increase its absorption (Schaefer 20007, p 766).

Alternatives

We do not have alternatives for Urea since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Urea is also known as


Urea in other languages or writings:

Group

Urea belongs to this group or family:

Tradenames

Main tradenames from several countries containing Urea in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 60 daltons
pKa 15,7 -

References

  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  2. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  3. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  4. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007

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