Last update: Feb. 10, 2019

Sulfathiazole

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

A short-acting sulfonamide with similar properties to sulfamethoxazole. Rarely administered systemically due to its toxicity (Toxnet 2009).
Used topically along with other medications for the treatment of vaginal, dermatological, ocular, otic and gastrointestinal infections.

Since the last update we have not found published data on its excretion in breastmilk.

Sulfonamides are excreted in small amounts in breastmilk: 6 to 94 micrograms/ml, 1.6% of the total dose (Briggs 2017). Reports of adverse effects are rare.

An old publication reports cases of diarrhea and rash in children breastfed by mothers who were being treated with sulfathiazole. (Von Freissen 1951).

Sulfathiazole is absorbed in very small amounts through the dermis (Waud 1944) and the intestine (Lasca 2018).

The small dose and poor plasma absorption of most topical ophthalmological, otic and dermatological preparations make it unlikely that significant amounts will transfer into breastmilk.

Do not apply to the chest in order to prevent the infant from ingesting it; if necessary, apply after a feed and clean well with water before the next one.

Alternatives

We do not have alternatives for Sulfathiazole.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sulfathiazole is also known as


Sulfathiazole in other languages or writings:

Tradenames

Main tradenames from several countries containing Sulfathiazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 10 %
Molecular weight 255 daltons
Protein Binding 60 %
pKa 7,2 -
Tmax 3 - 4 hours
T1/2 4 - 5 hours

References

  1. Lasca. Sulfatiazol. Ficha técnica. 2018 Full text (in our servers)
  2. Taku-E. Sulfathiazole. Drug Summary. 2018 Full text (in our servers)
  3. Toxnet. Sulfathiazole. 2009 Full text (link to original source) Full text (in our servers)
  4. VON FRIESEN B. A study of small dose sulphamerazine prophylaxis in obstetrics, including investigations on the transmission of the drug to foetal blood and urine, amniotic fluid and breast milk. Acta Obstet Gynecol Scand Suppl. 1951 Abstract
  5. Waud RA. The Absorption of Sulfathiazole from Wounds. Can Med Assoc J. 1944 Abstract
  6. Sadusk JF, Blake FG, Seymour A. Observations on the Absorption, Excretion, Diffusion, and Acetylation of Sulfathiazole in Man. Yale J Biol Med. 1940 Abstract

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