Last update: Aug. 6, 2017


Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Used alone or in combination with sofosbuvir in the treatment of hepatitis C.

Since the last update we have not found published data on its excretion in breast milk.

Its pharmacokinetic data (slightly elevated molecular weight and very high percentage of plasma protein binding) make it very unlikely that significant amounts will pass into milk, so that although there is disagreement (Thompson 2016), other experts believe that treatment with Simeprevir, on its own or in combination with Sofosbuvir is not contraindicated during breastfeeding (LactMed 2016,

See below the information of these related products:


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Simeprevir is also known as

Simeprevir in other languages or writings:


Simeprevir belongs to this group or family:


Main tradenames from several countries containing Simeprevir in its composition:


Variable Value Unit
Oral Bioavail. 62 %
Molecular weight 750 daltons
Protein Binding 99,9 %
Tmax 4 - 6 hours
T1/2 10 - 41 hours


  1. LactMed. Simeprevir. Full Record Display. 2017 Full text (in our servers)
  2. EMA. Simeprevir. Drug Summary. 2017 Full text (in our servers)
  3. EMA. Simeprevir. Ficha técnica. 2017 Full text (in our servers)
  4. Thompson AJ. Australian recommendations for the management of hepatitis C virus infection: a consensus statement. Med J Aust. 2016 Abstract Full text (link to original source) Full text (in our servers)
  5. Spera AM, Eldin TK, Tosone G, Orlando R. Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women? World J Hepatol. 2016 Abstract Full text (link to original source) Full text (in our servers)

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