Last update: Dec. 4, 2020

Riluzole

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

A glutamate antagonist, indicated in the treatment of amyotrophic lateral sclerosis.
Oral administration in two daily doses.

Its pharmacokinetic data (large volume of distribution and high percentage of protein binding) explain the very low transfer into breastmilk observed.

In addition, absorption decreases with fatty foods, so that the little amount that does reach breastmilk will be less absorbed by the infant.

Until there is more published data on this drug in relation to breastfeeding, known safer alternatives during the neonatal period and in the event of prematurity may be preferable.

Alternatives

We do not have alternatives for Riluzole.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Riluzole in other languages or writings:

Group

Riluzole belongs to this group or family:

Tradenames

Main tradenames from several countries containing Riluzole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 234 daltons
Protein Binding 97 %
VD 3,4 l/Kg
Tmax 1 - 2 hours
T1/2 9 - 15 hours
Theoretical Dose 0,0142 mg/Kg/d
Relative Dose 0.84 %

References

  1. Datta P, Rewers-Felkins K, Aurora N, Baker T, Hale TW. Estimation of Riluzole Levels in Human Milk and Infant Exposure During Its Use in a Patient With ALS. J Hum Lact. 2018 May;34(2):355-357. Abstract
  2. EMA - Sanofis. Riluzole (Rilutek). Drug Summary. 2006 Full text (in our servers)
  3. EMA - Sanofis. Riluzol (Rilutek). Ficha técnica. 2006 Full text (in our servers)

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