Last update: Aug. 26, 2014


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Used as treatment of malaria and toxoplasmosis.

Give folic acid or similar as pyrimethamine has an antagonistic effect on this vitamin.

Avoid its use on patients suffering of G-6-P dehydrogenasa.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.


We do not have alternatives for Pyrimethamine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Pyrimethamine belongs to this group or family:


Main tradenames from several countries containing Pyrimethamine in its composition:

  • Daraprim
  • Pyramet™. Contains other elements than Pyrimethamine in its composition


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 249 daltons
Protein Binding 87 %
Tmax 6 hours
T1/2 96 hours
M/P ratio 0,7 -
Theoretical Dose 0,5 mg/Kg/d
Relative Dose 50 %
Relat.Ped.Dose 25 - 50 %


  1. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  2. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by La Liga de la Leche de México from Mexico

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