Last update: Aug. 17, 2019
Not risky for breastfeeding or infant.
Enzymes which are able to hydrolyze proteins.
They are found in all living beings and are an important part of digestive enzymes: pancreatic (trypsin and chymotrypsin) and gastric (pepsin)..
They are orally used for gastrointestinal disorders and topically on wounds and burns. Some (chymotrypsin) are used in cataract surgery.
There is an increasing trend on type and therapeutic uses (Craik 2011). There is no evidence of its efficacy in the treatment of post-traumatic or post-surgical inflammations or in respiratory diseases.
At latest update relevant published data on excretion into breast milk were not found.
Because the small dose used and low plasma uptake of most topical dermatological and ophthalmological preparations it is unlikely that significant amounts of it will pass into breastmilk.
Its high molecular weight turns further improbable any excretion into breastmilk.
Due to its protein nature, when orally taken it is digested by the infant’s intestine, hence its absorption and passage to plasma should be nil.
The manufacturer considers it compatible with breastfeeding (AEMPS 2016).
Few studies with low levels of evidence on oral use of proteases to alleviate breast congestion have shown uneven results (ABM 2016, Mangesi 2016).
We do not have alternatives for Proteases since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) from Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM