Last update: Oct. 15, 2014


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

It is an anti-malaria compound that combines Proguanil with Atovacuona. Proguanil is considered to be an essential drug and compatible with BF by WHO.


We do not have alternatives for Proguanil since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Proguanil belongs to this group or family:


Main tradenames from several countries containing Proguanil in its composition:

  • Laveran
  • Malanil™. Contains other elements than Proguanil in its composition
  • Malarone™. Contains other elements than Proguanil in its composition
  • Paludrine
  • Promal™. Contains other elements than Proguanil in its composition
  • Savarine


Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 253 daltons
Protein Binding 75 %
Tmax 4 hours
T1/2 21 hours


  1. Arguin PM, Tan KR. Chemoprophylaxis during Pregnancy and Breastfeeding In Chapter 3. Infections diseases related to travel. Malaria. In Centers for Disease Control and Prevention. CDC Health Information for International Travel 2014. 2014 Full text (link to original source) Full text (in our servers)
  2. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  3. [No authors listed] Atovaquone + proguanil: new indication. For children weighing as little as 5 kg; an inconvenient form. A flavoured syrup would be better suited to infants and young children. Prescrire Int. 2009 Abstract
  4. Pérez JL, Carranza C, Mateos F. Antiparasitarios. Revisión de los fármacos útiles en el tratamiento de parasitosis clásicas y emergentes. \ [Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases]. Rev Esp Quimioter. 2009 Jun;22(2):93-105. Review. Spanish. Abstract Full text (link to original source) Full text (in our servers)
  5. Borrmann S, Faucher JF, Bagaphou T, Missinou MA, Binder RK, Pabisch S, Rezbach P, Matsiegui PB, Lell B, Miller G, Kremsner PG. Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children. Clin Infect Dis. 2003 Abstract Full text (in our servers)
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  7. Edstein MD, Veenendaal JR, Scott HV, Rieckmann KH. Steady-state kinetics of proguanil and its active metabolite, cycloguanil, in man. Chemotherapy. 1988 Abstract
  8. CHARLES LJ. Field trials with chlorproguanil in the prophylaxis of malaria in Ghana. Bull World Health Organ. 1961 Abstract Full text (in our servers)

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e-lactancia is a resource recommended by La Liga de la Leche, España from Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM