Last update: Jan. 4, 2015

Pancuronium Bromide

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation.

At latest update, no relevant published data concerning excretion into breast milk were found.

Because a relatively high molecular-weight and a high protein-binding capacity, excretion into breast milk is thought to be low. It has a low oral bioavailability which means that absorption from the breast milk ingested may be low.

Pancuronium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in good condition.

However, other muscle relaxants with a more rapid elimination time period and better known drugs are preferred.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Pancuronium Bromide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Pancuronium Bromide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 733 daltons
Protein Binding 85 %
VD 0,2 l/Kg
T1/2 1,5 - 3 hours

References

  1. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014 Abstract
  2. Ferriols Lisart R,Ferriols Lisart F. Farmacología clínica y usos terapéuticos del Mivacurio. Farm Hosp. 1997 Full text (in our servers)
  3. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994 Abstract
  4. Dailey PA, Fisher DM, Shnider SM, Baysinger CL, Shinohara Y, Miller RD, Abboud TK, Kim KC. Pharmacokinetics, placental transfer, and neonatal effects of vecuronium and pancuronium administered during cesarean section. Anesthesiology. 1984 Abstract
  5. Somogyi AA, Shanks CA, Triggs EJ. Clinical pharmacokinetics of pancuronium bromide. Eur J Clin Pharmacol. 1976 Abstract

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