Last update: Feb. 20, 2015

Nystatin

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

At latest update, relevant published data on excretion into breast milk were not found.

Absorption through the skin and mucosa is nil, in addition it is known to be almost nil via gastrointestinal tract. Hence, it is unlikely its appearance in the mother's plasma or the milk.

Authorized medication for use in small infants and newborns.

It is recommended to avoid putting creams, gels and other products for local use that could contain paraffin (mineral oil) on the nipple, in order to keep from absorbing it by the child.

WHO Model List of Essential Medicines (2002): compatible with breastfeeding.

Alternatives

We do not have alternatives for Nystatin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Nystatin is also known as


Groups

Nystatin belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Nystatin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 926 daltons

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. Kiat-Amnuay S, Bouquot J. Breastfeeding keratosis: this frictional keratosis of newborns may mimic thrush. Pediatrics. 2013 Abstract Full text (link to original source) Full text (in our servers)
  3. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Abstract Full text (link to original source) Full text (in our servers)
  4. Hoeger PH, Stark S, Jost G. Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study. J Eur Acad Dermatol Venereol. 2010 Abstract
  5. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  6. Nystatin. Drug Summary. 2006 Full text (in our servers)
  7. Ilett KF, Kristensen JH. Drug use and breastfeeding. Expert Opin Drug Saf. 2005 Abstract
  8. de Vries TW, Wewerinke ME, de Langen JJ. [Near asphyxiation of a neonate due to miconazole oral gel]. Ned Tijdschr Geneeskd. 2004 Abstract
  9. Nistatina. Ficha técnica. 2004 Full text (in our servers)
  10. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  11. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  12. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  13. Brent NB. Thrush in the breastfeeding dyad: results of a survey on diagnosis and treatment. Clin Pediatr (Phila). 2001 Abstract
  14. Hoover K. Breast pain during lactation that resolved with fluconazole: two case studies. J Hum Lact. 1999 Abstract
  15. Bodley V, Powers D. Long-term treatment of a breastfeeding mother with fluconazole-resolved nipple pain caused by yeast: a case study. J Hum Lact. 1997 Abstract
  16. Dhondt F, Ninane J, De Beule K, Dhondt A, Cauwenbergh G. Oral candidosis: treatment with absorbable and non-absorbable antifungal agents in children. Mycoses. 1992 Abstract

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