Last update: Oct. 4, 2020

モダフィニル

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

Central stimulant, selective inhibitor of dopamine and norepinephrine reuptake.
Modafinil is a racemic mixture of its R enantiomer and its S enantiomer. The R enantiomer, known as armodafinil, is pharmacologically active, while the S enantiomer is inactive (Aurora 2018).
Used in narcolepsy.
Oral administration in one or two daily doses.

Modafinil is excreted in breastmilk in clinically insignificant amounts (Aurora 2018) and no problems have been observed in six infants whose mothers were taking modafinil (Calvo 2018).

Modafinil can reduce prolactin levels (Samuels 2006).

A mother reported nervousness and sleeping difficulties in her breastfed daughters, which forced her to suspend treatment (age of girls and doses unspecified).

Until there is further published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in cases of prematurity.


See below the information of these related products:

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

モダフィニル is Modafinil in Japanese.

Is written in other languages:

Group

モダフィニル belongs to this group or family:

Tradenames

Main tradenames from several countries containing モダフィニル in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 273 daltons
Protein Binding 60 %
VD 0,9 l/Kg
pKa 8,84 -
Tmax 2 - 4 hours
T1/2 15 hours
Theoretical Dose 0,18 mg/Kg/d
Relative Dose 5,3 %

References

  1. AEMPS. Modafinilo. Ficha técnica. 2019 Full text (in our servers)
  2. Calvo-Ferrandiz E, Peraita-Adrados R. Narcolepsy with cataplexy and pregnancy: a case-control study. J Sleep Res. 2018 Apr;27(2):268-272. Abstract Full text (link to original source)
  3. Aurora S, Aurora N, Datta P, Rewers-Felkins K, Baker T, Hale TW. Evaluating Transfer of Modafinil Into Human Milk During Lactation: A Case Report. J Clin Sleep Med. 2018 Dec 15;14(12):2087-2089. Abstract Full text (link to original source) Full text (in our servers)
  4. FDA. Modafinil (Provigil). Drug Summary. 2010 Full text (link to original source) Full text (in our servers)
  5. Wise MS, Arand DL, Auger RR, Brooks SN, Watson NF; American Academy of Sleep Medicine. Treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007 Abstract Full text (link to original source) Full text (in our servers)

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