Last update: June 10, 2018

MMA

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Methyl methacrylate (MMA) forms the basis of acrylic bone cements used in orthopedic surgery and also in dental repairs and intraocular lenses.

During its preparation, generally in the operating room, there may be exposure to vapours which irritate the respiratory tract, eyes and skin, without the ability to gauge significant toxic effects with acute exposure (Muttray 2015), nor measure detectable levels in the plasma (Homlar 2013 ) or breastmilk (Linehan 2006) of the personnel who are exposed.

The threshold limit values ​​for daily exposure of 50 ppm (208 mg/m3) and the threshold limit values ​​for short-term exposure of 100 ppm (416 mg/m3) (Muttray 2015, Rosell 2008), are difficult to reach if adequate protection systems are used (Downes 2014, Rosell 2008). Most exposed is the person who prepares the cement.
Exposure is minimized by ventilation systems, use of double gloves, goggles and respiratory masks with an adequate filter and, above all, by the use of closed preparation systems (Downes 2014, Rosell 2008).

Very low levels of MMA have been measured in breastmilk after an arthroplasty with methylmethacrylate was performed on a breastfeeding mother, so it would not be necessary to interrupt breastfeeding (Hersh 1995).

Alternatives

We do not have alternatives for MMA since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

MMA belongs to this group or family:

Tradenames

Main tradenames from several countries containing MMA in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 100 daltons

References

  1. Muttray A, Gosepath J, Brieger J, Faldum A, Zagar C, Mayer-Popken O, Jung D, Roßbach B, Mann W, Letzel S. No acute effects of an exposure to 50 ppm methyl methacrylate on the upper airways. Int Arch Occup Environ Health. 2015 Abstract
  2. Downes J, Rauk PN, Vanheest AE. Occupational hazards for pregnant or lactating women in the orthopaedic operating room. J Am Acad Orthop Surg. 2014 Abstract
  3. Homlar KC, Sellers MH, Halpern JL, Seeley EH, Holt GE. Serum levels of methyl methacrylate following inhalational exposure to polymethylmethacrylate bone cement. J Arthroplasty. 2013 Abstract
  4. Wright. Cemento Óseo Orthoset. Ficha técnica 2012 Full text (in our servers)
  5. Rosell Farrás MG, Méndez Liz MJ. Cementos óseos: prevención de la exposición a sus componentes durante su preparación. Notas Técnicas de prevención. 2008 Full text (link to original source) Full text (in our servers)
  6. Linehan CM, Gioe TJ. Serum and breast milk levels of methylmethacrylate following surgeon exposure during arthroplasty. J Bone Joint Surg Am. 2006 Abstract
  7. Hersh J, Bono JV, Padgett DE, Mancuso CA. Methyl methacrylate levels in the breast milk of a patient after total hip arthroplasty. J Arthroplasty. 1995 Abstract

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