Last update: July 11, 2016

Misoprostol

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Prostaglandin E1 analogue that is used in the prevention of gastroduodenal ulcers associated with the use of NSAIDs and induction of labor and abortion provocation.

It is found naturally in milk and colostrum.

It is excreted in breast milk in clinically non-significant amount with a very short half-life span.

Follow-up for intestinal colic or diarrhea in the infant.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Misoprostol belongs to this group or family:

Tradenames

Main tradenames from several countries containing Misoprostol in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 88-100 %
Molecular weight 383 daltons
Protein Binding 80 -90 %
Tmax 0,3 - 1 hours
T1/2 0,3 - 0,6 hours
M/P ratio 0,05 -
Theoretical Dose < 0,000001 mg/Kg/d
Relative Dose < 0,034 %

References

  1. FLASOG. Uso del Misoprostol en Obstetricia y Ginecología. Monografía. 2013 Full text (in our servers)
  2. Sääv I, Fiala C, Hämäläinen JM, Heikinheimo O, Gemzell-Danielsson K. Medical abortion in lactating women--low levels of mifepristone in breast milk. Acta Obstet Gynecol Scand. 2010 Abstract
  3. Guerra GV, Cecatti JG, Souza JP, Faúndes A, Morais SS, Gülmezoglu AM, Parpinelli MA, Passini R Jr, Carroli G; World Health Organisation 2005 Global Survey on Maternal and Perinatal Health Research Group. Factors and outcomes associated with the induction of labour in Latin America. BJOG. 2009 Dec;116(13):1762-72. Abstract Full text (link to original source) Full text (in our servers)
  4. Misoprostol. Data Sheet. 2009 Full text (in our servers)
  5. Vogel D, Burkhardt T, Rentsch K, Schweer H, Watzer B, Zimmermann R, Von Mandach U. Misoprostol versus methylergometrine: pharmacokinetics in human milk. Am J Obstet Gynecol. 2004 Abstract
  6. Abdel-Aleem H, Villar J, Gülmezoglu AM, Mostafa SA, Youssef AA, Shokry M, Watzer B. The pharmacokinetics of the prostaglandin E1 analogue misoprostol in plasma and colostrum after postpartum oral administration. Eur J Obstet Gynecol Reprod Biol. 2003 Abstract
  7. Shimizu T, Yamashiro Y, Yabuta K. Prostaglandin E1, E2, and F2 alpha in human milk and plasma. Biol Neonate. 1992 Abstract
  8. Bremme K, Eneroth P, Bygdeman M. Maternal serum hormone changes during abortion induced with 16,16-dimethyl-trans-delta 2-PGE1 methyl ester. Prostaglandins Leukot Med. 1982 Abstract

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