Last update: July 24, 2014


High Risk for breastfeeding

Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

Although it is secreted into breast milk it has not been detected in infant’s blood because it forms non absorbable chelate compounds with milk calcium. It is not convenient a prolonged use (more than 3-4 weeks) for a potential damage on bone growth plates, teeth discoloration, or alteration of intestinal flora. Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.
Not commercially available in Spain


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Metacycline-Hcl belongs to this group or family:


Main tradenames from several countries containing Metacycline-Hcl in its composition:


Variable Value Unit
Oral Bioavail. 58 %
Molecular weight 479 daltons
Protein Binding 80 %
Tmax 3 hours
T1/2 15 hours
M/P ratio 0,5 -


  1. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 from United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM