Last update: March 23, 2018

Levocetirizine

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Second generation antihistamine, derived from piperazine, with minimal sedative effects and very low toxicity even at high doses.

Since the last update we have not found published data on its excretion in breast milk, but it is an enantiomer and active metabolite of cetirizine.

No problems were detected in the short or long term in an infant whose mother took cetirizine during the first month after delivery as part of the treatment for pemphigus (Westermann 2012). Its high binding to plasma proteins makes its transfer to milk unlikely.

The British Society for Allergy and Clinical Immunology considers cetirizine safe during breastfeeding (Powell 2007).


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Levocetirizine is also known as


Levocetirizine in other languages or writings:

Group

Levocetirizine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Levocetirizine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 389 daltons
Protein Binding 92 %
VD 0,4 l/Kg
Tmax 1 hours
T1/2 8 - 12 hours

References

  1. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012 Abstract
  2. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007 Abstract Full text (link to original source) Full text (in our servers)

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