Last update: Aug. 17, 2019

Lactitol monohydrate

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Synthetic derivative of lactulose. It is a disaccharide analogue of lactulose with similar action and uses.
It does not hydrolyze in the intestine, so it is not absorbed, reaching the colon intact, where it exerts its function as an osmotic laxative (AEMPS 2015, Würsch 1989, Metzger 1988). Indicated in constipation and hepatic encephalopathy.
Oral administration in a daily dose.

Since the last update we have not found published data on its excretion in breastmilk.

Its virtually zero oral bioavailability makes plasma levels null and therefore does not transfer to breastmilk (AEMPS 2015, P-RMS 2010).

For the same reason, it impedes transfer from breastmilk to infant plasma.


See below the information of this related product:

Alternatives

We do not have alternatives for Lactitol monohydrate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Lactitol monohydrate is also known as Lactitol. Here it is a list of alternative known names::


Lactitol monohydrate in other languages or writings:

Group

Lactitol monohydrate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Lactitol monohydrate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 1 %
Molecular weight 344 daltons
pKa 12,1 -

References

  1. AEMPS. Lactitol (Emportal). Ficha técnica. 2015 Full text (in our servers)
  2. P-RMS. Lactitol (Importal). Drug Summary. 2010 Full text (in our servers)
  3. Würsch P, Koellreutter B, Schweizer TF. Hydrogen excretion after ingestion of five different sugar alcohols and lactulose. Eur J Clin Nutr. 1989 Dec;43(12):819-25. Abstract
  4. Metzger J, Chollet C, Wermeille M, Biollaz J, Llull JB, Lauterburg BH. Lactitol: gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis. Eur J Clin Pharmacol. 1988;35(1):97-9. Abstract

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