Last update: April 9, 2018

Iodine-125

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

It has physical half-life of 1445 hours (60.2 days). However, the effective half-life is a function of the biological half-life of every I-125 compound.

I-125 OIH (sodium ortho-iodide hyppurate) is used for testing. It has an effective half-life of 6 hours. By a nursing interruption of 2 days there is no risk of irradiation in the infant.

For other I-125 compounds like I-125 HSA (Human serum albumin) and I-125 Fibrinogen 3 weeks of nursing interruption are recommended.

Whenever the continuation of breastfeeding is desired, it is advisable to start pumping and milk may be used to feed the infant while nursing is being interrupted whether alone or together with formula. Once the test is over, mother’s milk may be pumped and it must be discarded. It is not worth storing in a separate freezer, since 10 average physical lives, after which the radiation will have disappeared, suppose 600 days.

Radiation level in breast milk can be tested.

The shortest half-life radio-nuclide must be chosen whenever possible.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Iodine-125 is also known as


Pharmacokinetics

Variable Value Unit
T1/2 1440 hours
M/P ratio 25 -

References

  1. ARSAC: Administration of Radioactive Substances Advisory Committee. Notes for Guidance on the Clinical Administration of Radiopharmaceuticals and Use of Sealed Radioactive Sources. Section 7 Conception, Pregnancy and Breastfeeding, p. 47-53. ARSAC Support Unit. Centre for Radiation, Chemical and Environmental Hazards. Public Health England. 2019 Abstract Full text (link to original source) Full text (in our servers)
  2. Leide-Svegborn S, Ahlgren L, Johansson L, Mattsson S. Excretion of radionuclides in human breast milk after nuclear medicine examinations. Biokinetic and dosimetric data and recommendations on breastfeeding interruption. Eur J Nucl Med Mol Imaging. 2016 Abstract
  3. US.NRC - Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. Apéndice U, Tabla U.3. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Draft Report for Comment. Appendix U, Table U.3. NUREG-1556. Vol.9, Rev 3. 2016 Full text (link to original source) Full text (in our servers)
  4. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  5. ICRP. Radiation dose to patients from radiopharmaceuticals. Addendum 3 to ICRP Publication 53. ICRP Publication 106. Annex D. Recommendations on breast-feeding interruptions, p. 163-165. Ann ICRP. 2008 Abstract Full text (link to original source) Full text (in our servers)
  6. US.NRC - Howe DB, Beardsley M, Bakhsh S. U.S. Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. Apéndice U, Tabla U.3. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Final report. Appendix U, Table U.3. NUREG-556. Vol.9, Rev 2. 2008 Full text (link to original source) Full text (in our servers)
  7. Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: mechanisms, findings, and radiation dosimetry. J Nucl Med. 2000 Abstract Full text (link to original source) Full text (in our servers)
  8. Ahlgren L. Excretion of radionuclides in human breast milk after administration of radiopharmaceuticals. Error in table. J Nucl Med. 1986 Abstract Full text (link to original source) Full text (in our servers)
  9. Ahlgren L, Ivarsson S, Johansson L, Mattsson S, Nosslin B. Excretion of radionuclides in human breast milk after the administration of radiopharmaceuticals. J Nucl Med. 1985 Abstract Full text (link to original source) Full text (in our servers)

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