Last update: June 10, 2018


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

A bactericidal and fungicidal antiseptic.
Used topically in mild mucus infections (vaginal, 0.1% mouthwash for oral hygiene).

Since the last update we have not found published data on its excretion in breast milk.

The small dose and low plasma absorption of most topical preparations make it unlikely that significant amounts will be transferred into breastmilk, as stated in information for hexetidine (McNeil Products Ltd 2017).

A case of contact dermatitis has been documented following its use (Merk 1982), so contact should be avoided with mucous membranes or the baby’s skin.

As an oral antiseptic it is much less effective than chlorhexidine (Afennich 2011).


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Hexetidine in other languages or writings:


Main tradenames from several countries containing Hexetidine in its composition:


Variable Value Unit
Molecular weight 340 daltons


  1. McNeil Products Ltd. Oraldene (Hexetidine). Drug Summary. 2017 Full text (in our servers)
  2. Afennich F, Slot DE, Hossainian N, Van der Weijden GA. The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review. Int J Dent Hyg. 2011 Abstract
  3. Parke Davis. Hexetidina. Ficha técnica. 2000 Full text (in our servers)
  4. Merk H, Ebert L, Goerz G. Allergic contact dermatitis due to the fungicide hexetidine. Contact Dermatitis. 1982 Abstract

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