Last update: March 30, 2021
Minimal risk for breastfeeding and infant.
It is indicated for prophylaxis and treatment of venous or arterial thrombosis, pulmonary embolism and acute coronary syndrome.
Authorized use in neonates and infants.
Intravenous or subcutaneous use.
We did not find published data regarding the excretion of this substance through breast milk at the time this last update was completed.
The high molecular weight of both standard or non-fractionated Heparin and low molecular weight heparins makes it very unlikely to pass into breast milk in a significant quantity (Pfizer2016); manufacturers claim that it is not excreted in breast milk (AEMPS 2017, Hospira 2014).
In addition, heparins are inactivated in the gastrointestinal tract, not being absorbed (practically nil oral bioavailability), which prevents the passage into plasma of the infant from ingested breast milk (Pfizer2016).
There is virtually no excretion in human milk of other low molecular weight heparins such as dalteparin (Richter 2001) and there is an absence of anticoagulant activity in plasma of infants breastfed by mothers treated with enoxaparin (Guillonneau 1996).
Risk of Heparin-induced Thrombocytopenia and Osteoporosis in the mother is lower with low molecular weight heparins (Fuller 2013, Middeldorp 2011, Rath 2010).
Several medical societies, experts authors and expert consensus, consider the use of this medication to be safe or very probably safe during breastfeeding (Hale, Lactmed, Bates 2018 y 1997, Briggs 2015, Schaefer 2015, Rowe 2013, Fuller 2013, Yurdakök 2012, Rath 2010).
Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding (WHO 2000).
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
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