Last update: Jan. 17, 2016
Minimal risk for breastfeeding and infant.
Vasodilator used to treat cardiac disorders like ischemia and mainly anal fissures.
It is also used during pregnancy as a tocolytic drug in cases of threatened preterm labor and eclampsia.
It has been used to treat heart disorders in babies and children. Even to treat anal fissures in children under 1 year, and noteworthy, in ischemic issues on premature infants without side effects.
It is administered intravenously, orally, sublingually, on skin patches, ointment ...
Because of a moderately-high volume of distribution and very fast metabolism (Tmax and t1 / 2 minutes) it is highly unlikely the passage of significant amounts to the breast milk, especially when applied topically. This explains why it has not been observed any troubles in 40 infants whose mothers with anal fissures were treated with nitroglycerin ointment application even for periods of 12 months. Mothers have complained of headaches that commonly occur with the use of various vasodilators drugs.
The amount of nitrate / nitrite in this type of vasodilator drugs is of few milligrams, therefore, toxicity associated to nitrates such as methemoglobinemia in breastfed infants from treated mothers has not been reported (The dose of nitrite is Rectogesic 1.5 mg / 12 hours).
We do not have alternatives for Glyceryl Trinitrate since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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